Indicators of prescription drug use may include which of the following?

Pupil contraction is a common physiological response associated with the use of certain prescription drugs, particularly opioids and some sedatives. These substances can cause the pupils to constrict, a condition known as miosis. This specific reaction occurs due to the way these drugs interact with the body's nervous system, affecting the muscles that control pupil size.

In the context of judging prescription drug use, observing an individual with significantly constricted pupils may indicate possible intoxication or dependence on these types of medications. Other physiological signs like clumsiness or body overheating may relate to various other factors, and while they can indicate intoxication, they are not as definitive for prescription drugs specifically. Profuse respiration does not align with typical effects seen in prescription drug users and is more often associated with different health conditions or substance use effects.