What is defined as the use of a dangerously large amount of a substance?

The term that describes the use of a dangerously large amount of a substance is "overdose." When a person consumes a substance in quantities that overwhelm the body's ability to process it safely, it can lead to severe health consequences, including potential death. Overdoses can occur with various substances, such as drugs and alcohol, and typically require immediate medical attention to mitigate life-threatening effects.

Other options represent different concepts. Detoxification refers to the process of removing toxic substances from the body, usually under medical supervision. Withdrawal describes the symptoms that occur when a person stops or reduces intake of a substance they are dependent on. Psychological dependence is a condition where an individual feels a compulsion to use a substance to cope with psychological issues, not necessarily involving the quantifiable measure of substance use represented by an overdose.