Which of the following descriptions best describes Schedule II substances?

Schedule II substances are categorized as having a high potential for abuse but also possess accepted medical uses, albeit with stringent restrictions. This classification indicates that while these substances can be effective for medical treatment—such as certain opioids used for pain management—they come with a significant risk of addiction, abuse, and dependency. This necessitates careful regulation and monitoring by both medical professionals and law enforcement.

In contrast, other classifications, such as Schedule I substances, are considered to have no accepted medical use and a high potential for abuse, while Schedule III substances have a moderate potential for abuse compared to those in Schedule II. The description mentioning over-the-counter medications pertains more accurately to substances classified outside of Schedule II, as Schedule II substances are typically prescription medications rather than those that can be obtained freely without a prescription.