Which of the following indicates moderate physical dependence?

Moderate physical dependence is best indicated by substances classified under Schedule III. Schedule III substances are defined as drugs that have a potential for moderate abuse and dependency compared to those in higher schedules. They may cause physical dependence or high psychological dependence.

For example, anabolic steroids and certain compounds containing hydrocodone fall into this category. These can lead to moderate physical dependence, reflecting the potential for addiction but recognizing that the risk and severity are not as high as those seen with Schedule II substances, which are categorized as having a higher potential for abuse and severe dependence.

In contrast, Schedule I substances are considered to have no accepted medical use and a high potential for abuse, while Schedule II substances have a high potential for abuse and lead to severe physical or psychological dependence. Schedule IV substances have a lower potential for abuse compared to the higher schedule categories, indicating a lesser degree of dependence overall.